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Chelsea Handler can't stand Reese Witherspoon. That's the gag in the latest episode of Handler's show After Lately, on which Witherspoon will made her second cameo this weekend, according to Pop Sugar.

In the clip, a perky Witherspoon sits at an office table along with Handler and her staffers. "I made you a little something to say thank you for all of your hard work. I'll be right back, it's right upstairs," Witherspoon says sunnily before exiting the room. As soon as she's gone, a frustrated Chelsea vents her feelings. "Oh my god, she is driving me crazy. You guys were right the last time, she is so awful!"

Her appearances on After Lately have allowed the newly remarried Witherspoon to have some fun with her squeaky clean, A-list image. Last year she morphed from America's sweetheart into a tyrant. "You guys are a bunch of narcissistic jerks. It's like Chelsea is running an animal shelter around here, except she's not rescuing a bunch of cats and dogs, she's rescuing failures," she said, berating Handler's staff.

In actuality, Witherspoon and Handler are good pals. They're also co-starring in This Means War, alongside Tom Hardy, which is due out in theaters on Valentine's Day.

Watch the clip here:

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